Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.
A patient mentioned, "I have taken the Xgeva shot once and I felt a pain in my neck on the way home from my Doctors office. The next day I could not turn my head left or right it was the worse pain I have felt since my cancer returned. Not only that, it made my legs, hip, jaw hurt and it makes my whole body throb in my chest and lower back and and now I can't lift my left arm and I have night sweats as if someone poured water on me . I have to see my Doctor on Tuesday and I'm suppose to take my second shot but I'm never going to take it again"