Palonosetron, trade name Aloxi is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting. It is used for the control of delayed CINV—nausea and vomiting and there are tentative data to suggest that it may be more effective than granisetron.
A disappointed pacient shared this in a review on webMD "Six hours after receiving Aloxi injection, experienced horrible headache that near migraine level. I have had a couple of migraines in my life but not a chronic problem. Had to use ice pack alternatively with heat to get relief and my pain pills did nothing (percoset) for relief. 48 hours after dosing, was given Fioriset to help control pain. Didn't have nausea from the chemo but did from the migraine. Dr. will try something different next infusion".
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"ALOXI (palonosetron) for Chemotherapy-induced Nausea and Vomiting"